Table 1.
Characteristics of the subjects by sex and BMI categories
| |
Men |
Women |
p gender and BMI interaction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lean | Overweight | Obese | p Kruskal Wallis | p linearity | Lean | Overweight | Obese | p Kruskal Wallis | p linearity | ||
| N |
23 |
18 |
10 |
|
|
14 |
9 |
13 |
|
|
|
| Age (years) |
33.1 ± 11.4 |
36.9 ± 9.3 |
38.3 ± 9.7 |
0.23 |
0.15 |
31.3 ± 12.9 |
35.3 ± 16.0 |
34.2 ± 10.7 |
0.70 |
0.56 |
0.91 |
| BMI ( kg/m2) |
22.1 ± 1.4 |
27.7 ± 1.7 |
35.3 ± 7.4 |
<0.001 |
<0.001 |
23.0 ± 1.4 |
27.7 ± 1.5 |
36.3 ± 5.9 |
<0.001 |
<0.001 |
0.86 |
| Percent fat (%) |
14.2 ± 3.6 |
23.2 ± 6.3 |
33.6 ± 9.6 |
<0.001 |
<0.001 |
26.6 ± 6.0 |
32.5 ± 8.0 |
40.8 ± 5.3 |
<0.001 |
<0.001 |
0.28 |
| Waist circumference (cm) |
76.0 ± 4.5 |
92.8 ± 8.4 |
109.0 ± 12.8 |
<0.001 |
<0.001 |
78.0 ± 6.7 |
85.4 ± 7.7 |
102.6 ± 11.4 |
<0.001 |
<0.001 |
0.09 |
| Hip circumference (cm) |
87.1 ± 5.9 |
97.2 ± 6.1 |
117.1 ± 15.1 |
<0.001 |
<0.001 |
92.0 ± 9.1 |
106.9 ± 9.7 |
119.8 ± 13.3 |
<0.001 |
<0.001 |
0.59 |
| Waist-to-hip ratio |
0.89 ± 0.03 |
0.93 ± 0.04 |
0.92 ± 0.05 |
0.12 |
0.10 |
0.85 ± 0.06 |
0.80 ± 0.04 |
0.88 ± 0.08 |
0.04 |
0.40 |
0.04 |
| Waist-to-height ratio |
0.44 ± 0.03 |
0.53 ± 0.05 |
0.63 ± 0.09 |
<0.001 |
<0.001 |
0.48 ± 0.05 |
0.52 ± 0.04 |
0.63 ± 0.07 |
<0.001 |
<0.001 |
0.10 |
| Systolic blood pressure (mmHg) |
122 ± 20 |
131 ± 21 |
129 ± 10 |
0.04 |
0.22 |
123 ± 22 |
117 ± 17 |
125 ± 6 |
0.29 |
0.91 |
0.34 |
| Diastolic blood pressure (mmHg) |
72 ± 9 |
76 ± 11 |
84 ± 6 |
0.006 |
0.002 |
75 ± 9 |
71 ± 6 |
77 ± 5 |
0.09 |
0.47 |
0.11 |
| Total cholesterol (mg/L) |
160 ± 43 |
210 ± 63 |
275 ± 45 |
0.002 |
<0.001 |
154 ± 61 |
182 ± 77 |
235 ± 55 |
0.02 |
0.009 |
0.67 |
| Triglycerides (mg/L) |
50 ± 17 |
57 ± 20 |
71 ± 47 |
0.42 |
0.17 |
54 ± 14 |
47 ± 15 |
71 ± 43 |
0.22 |
0.19 |
0.80 |
| HDL cholesterol (mg/L) |
48 ± 18 |
63 ± 21 |
70 ± 32 |
0.37 |
0.07 |
47 ± 20 |
39 ± 11 |
58 ± 23 |
0.10 |
0.22 |
0.37 |
| LDL cholesterol (mg/L) |
102 ± 40 |
136 ± 54 |
191 ± 80 |
0.02 |
0.006 |
96 ± 48 |
133 ± 81 |
163 ± 64 |
0.07 |
0.03 |
0.82 |
| Fasting glucose (mmol/L) |
4.56 ± 0.58 |
4.42 ± 0.55 |
4.93 ± 0.56 |
0.14 |
0.21 |
4.46 ± 0.50 |
4.85 ± 0.70 |
4.56 ± 043 |
0.20 |
0.61 |
0.04 |
| 2 h glucose (mmol/L) |
5.46 ± 1.24 |
5.26 ± 1.00 |
8.17 ± 3.40 |
0.002 |
0.003 |
6.36 ± 1.21 |
6.67 ± 1.68 |
7.02 ± 1.14 |
0.48 |
0.25 |
0.05 |
| Fasting insulin (mU/L) |
4.66 ± 2.56 |
5.71 ± 4.39 |
8.95 ± 3.60 |
0.01 |
0.007 |
6.72 ± 2.69 |
9.56 ± 5.94 |
7.38 ± 3.26 |
0.44 |
0.59 |
0.06 |
|
Euglycaemic clamp |
|
|
|
|
|
|
|
|
|
|
|
| M unadjusted (mg.min−1.kg−1) |
10.0 ± 2.7 |
7.5 ± 2.4 |
5.2 ± 1.8 |
<0.001 |
<0.001 |
8.4 ± 2.2 |
7.6 ± 2.8 |
6.1 ± 1.7 |
0.02 |
0.01 |
0.13 |
| M adjusted to lean mass (mg.min−1.kg−1) |
11.6 ± 2.9 |
9.8 ± 3.3 |
7.8 ± 2.9 |
0.004 |
0.001 |
11.5 ± 2.7 |
11.1 ± 3.4 |
10.4 ± 3.1 |
0.70 |
0.35 |
0.27 |
|
Fasting indices |
|
|
|
|
|
|
|
|
|
|
|
| Plasma insulin (mUI/mL) |
4.7 ± 2.6 |
5.7 ± 4.4 |
8.9 ± 3.6 |
0.01 |
0.007 |
6.7 ± 2.7 |
9.6 ± 5.9 |
7.4 ± 3.3 |
0.44 |
0.59 |
0.06 |
| Glucose/Insulin ratio (mmol/mUI) |
25.5 ± 18.7 |
21.6 ± 13.3 |
11.6 ± 4.9 |
0.03 |
0.07 |
15.7 ± 12.0 |
13.6 ± 12.1 |
14.0 ± 6.8 |
0.50 |
0.69 |
0.30 |
| HOMA-IR |
0.95 ± 0.57 |
1.11 ± 0.89 |
2.00 ± 0.93 |
0.009 |
0.004 |
1.33 ± 0.56 |
2.08 ± 1.32 |
1.53 ± 0.65 |
0.34 |
0.47 |
0.02 |
| FIRI |
0.85 ± 0.51 |
1.01 ± 0.80 |
1.80 ± 0.84 |
0.009 |
0.004 |
1.20 ± 0.50 |
1.88 ± 1.19 |
1.37 ± 0.58 |
0.34 |
0.47 |
0.02 |
| QUICKI | 0.30 ± 0.15 | 0.19 ± 0.10 | 0.11 ± 0.03 | 0.01 | 0.10 | 0.15 ± 0.08 | 0.13 ± 0.08 | 0.13 ± 0.03 | 0.37 | 0.46 | 0.32 |
BMI: body mass index; HDL: high density lipoprotein cholesterol; LDL: low density lipoprotein cholesterol; HOMA-IR: Homeostasis Model Assessment for insulin resistance; FIRI: fasting insulin resistance index; QUICKI: quantitative insulin sensitivity check index.