Table 2.
Current and recently (2010 and later) finished clinical trials for treating ICH#
| Intervention | Study name | Clinical trial # | Target | Outcome |
|---|---|---|---|---|
| Surgical Evacuation |
STICH II |
|
Multiple |
No benefit [140] |
| Surgical Evacuation/tPA |
MISTIE III |
NCT01827046 |
Multiple |
Ongoing |
| Blood pressure lowering agents |
ATACH-II |
NCT01176565 |
Hematoma expansion |
Ongoing |
| Blood pressure lowering agents |
INTERACT2 |
NCT00716079 |
Hematoma expansion |
Inconclusive*[43] |
| Blood pressure lowering agents |
ICH-ADAPT |
NCT00963976 |
Hematoma expansion |
Ongoing |
| Factor VIIa (for spot sign patients) |
SPOTLIGHT |
NCT01359202 |
Hematoma expansion |
Ongoing |
| Factor VIIa (for spot sign patients) |
STOP IT |
NCT00810888 |
Hematoma expansion |
Ongoing |
| Factor VIIa (reversal anticoagulants) |
|
NCT00770718 |
Hematoma expansion |
Terminated (poor recruitment) |
| Platelet Transfusion |
|
NCT00699621 |
Hematoma expansion |
Ongoing |
| Pioglitazone |
SHRINC |
NCT00827892 |
Hematoma resolution |
Ongoing |
| Deferoxamine |
iDEF |
NCT02175225 |
Iron toxicity |
Ongoing |
| Minocycline |
MACH |
NCT01805895 |
Inflammation |
Ongoing |
| Simvastatin |
|
NCT00718328 |
Multiple |
Terminated (poor recruitment) |
| Fluoxetine |
|
NCT01737541 |
Motor recovery |
Ongoing |
| Albumin |
|
NCT00990509 |
Multiple |
Terminated (PI move) |
| Hypothermia |
|
NCT01866384 |
Multiple |
Ongoing |
| Ibuprofen | NCT01530880 | Fever prevention | Ongoing |
Details on clinical trials can be found from the NIH (http://www.clinicaltrials.gov) and The Internet Stroke Center (http://www.strokecenter.org/trials/).
#For older clinical trials, the reader is referred to Keep et al. [5].
*The effect of acute blood pressure lowering did not quite reach statistical significance in the phase 3 INTERACT2 trial.