Figure 2.

Ultrastructural changes associated with apoptotic cell death induced by TNF-α (10 ng/mL) in WEHI-164 cells, a murine fibrosarcoma cell line. Panel (a) shows a cell with intact cytoplasm and organelles. Panel (b) shows a cell in early apoptosis with extensive protrusion and blebbing of the plasma membrane, cytoplasmic shrinkage, and nuclear fragmentation. Panel (c) shows a cell with chromatin condensation and compact granular masses around the nuclear membrane, as well as multiple apoptotic bodies in the cytoplasm.