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. Author manuscript; available in PMC: 2015 Jun 29.
Published in final edited form as: Curr Opin Microbiol. 2014 Jun 29;0:16–24. doi: 10.1016/j.mib.2014.05.018

Figure 2.

Figure 2

Biochemical reaction network of H2O2 in E. coli. The diagram highlights the complexity of the intracellular H2O2 reaction network. Reactions are grouped into categories of antioxidant enzymes, antioxidant metabolites, oxidative DNA damage, and oxidative protein damage. Enzyme abbreviations: Cat, catalase; Ahp, alkyl hydroperoxidase; Msr, methionine sulfoxide reductase; TrxR, thioredoxin reductase; Gor, glutathione reductase. Metabolite abbreviations: R-COCOOH, generic α-keto acid; R-COOH, carboxylic acid; Metsox, L-methionine-S-oxide; SSB, DNA single strand break; DSB, DNA double strand break; dG, deoxyguanosine; 8-OHdG, 8-hydroxy-2-deoxyguanosine; 8-oxodG, 8-oxo-7,8-dihydro-2’-deoxyguanosine; Trxred, reduced thioredoxin; Trxox, oxidized thioredoxin; GSH, reduced glutathione; GSSG, glutathione disulfide; P([4Fe-4S]), protein with [4Fe-4S] cluster; P([3Fe-4S]), damaged protein with [3Fe-4S] cluster; P(Cys-CH2-SH), protein-bound L-cysteine; -SOH, sulfenic acid; -SO2H, sulfinic acid; -SO3H, sulfonic acid; P(Pro), protein-bound L-proline; P(Arg), protein-bound L-arginine; P(Lys), protein-bound L-lysine; P(glut-semi), protein-bound glutamic semialdehyde; P(glut-amino), protein-bound aminoadipic semialdehyde.