Figure 4.

TREC content of naive CD4⁺ and CD8⁺ T-cells. TREC content shown as log copies per 10⁵ cells for (A) CD4⁺CD45R0⁻ and (B) CD8⁺CD45R0⁻ “naive” T-cells. Line, box, and whiskers represent median, IQR, and range, respectively. ANOVA (nonparametric): P = .004, P = .19 respectively; *significant intergroup difference by post hoc testing. Trend across groups was significant (P < .001) for CD4⁺ cells, with HIV-2-HV group having lowest TREC content values in naive cells, but not for CD8⁺ cells (P = .056). Abbreviations: ANOVA, analysis of variance; HIV, human immunodeficiency virus; HIV-2-HV, HIV-2 infected with high viral load (>1000 copies/mL); HIV-2-LV, HIV-2 infected with low viral load (<100 copies/mL); IQR, interquartile range; TREC, T-cell receptor excision circle.