Table 2.
Associations of breast cancer risk with ever NSAID use and duration of NSAID use, the Nashville Breast Health Study, 2001–2010
| Cases (n) | Controls (n) | OR (95% CI)a | OR (95% CI)b | |
|---|---|---|---|---|
| Regular use of any NSAIDs | ||||
| Non-users | 1,818 | 1,542 | 1.00 (ref.) | 1.00 (ref.) |
| Ever-users | 856 | 819 | 0.81 (0.71–0.91) | 0.78 (0.69–0.89) |
| Baby aspirin only | 336 | 289 | 0.82 (0.69–0.99) | 0.82 (0.69–0.99) |
| Other NSAIDs only | 407 | 380 | 0.86 (0.73–1.01) | 0.81 (0.69–0.95) |
| Both | 113 | 147 | 0.57 (0.44–0.74) | 0.52 (0.40–0.69) |
| Duration of any NSAIDs use (yrs) | ||||
| Non-users | 1,818 | 1,542 | 1.00 (ref.) | 1.00 (ref.) |
| Ever-users | ||||
| ≤4 | 315 | 337 | 0.72 (0.61–0.86) | 0.71 (0.60–0.85) |
| 5–9 | 249 | 234 | 0.84 (0.69–1.02) | 0.80 (0.66–0.98) |
| ≥10 | 292 | 248 | 0.90 (0.74–1.08) | 0.86 (0.71–1.05) |
a
Adjusted for age, race, education, and household income.
b
Additionally adjusted for personal history of benign breast disease, first-degree family history of breast cancer, menopausal status, history of live birth, age at first live birth, use of hormone replacement therapy, regular exercise, alcohol consumption, and cigarette smoking status.