Table 3.

Associations of breast cancer risk with ever NSAID use and duration of use according to BMI, the Nashville Breast Health Study, 2001–2010

All women	BMI < 25 kg/m2		BMI ≥ 25 kg/m2
	Cases/controls	OR (95% CI)a	Cases/controls	OR (95% CIa)
Regular use of any NSAIDsb
Non-users	698/722	1.00 (ref.)	1117/817	1.00 (ref.)
Ever-users	262/265	0.95 (0.77–1.17)	593/553	0.71 (0.60–0.83)
Baby aspirin only	116/105	0.99 (0.73–1.34)	219/184	0.74 (0.59–0.94)
Other NSAIDs only	120/128	0.93 (0.70–1.23)	287/255	0.75 (0.61–0.92)
Both	26/32	0.73 (0.42–1.26)	87/114	0.45 (0.33–0.62)
Duration of any NSAIDs use (yrs)
Non-users	698/722	1.00 (ref.)	1117/817	1.00 (ref.)
Ever-users
≤4	106/110	0.92 (0.68–1.23)	208/227	0.62 (0.50–0.78)
5–9	83/83	0.97 (0.70–1.36)	166/151	0.72 (0.56–0.92)
≥10	73/72	0.98 (0.68–1.40)	219/175	0.81 (0.64–1.02)
Postmenopausal women	BMI < 25 kg/m2		BMI ≥ 25 kg/m2
	Cases/controls	OR (95% CI)a	Cases/controls	OR (95% CI)a
Regular use of any NSAIDs
Non-users	382/340	1.00 (ref.)	685/472	1.00 (ref.)
Ever-users	191/196	0.89 (0.69–1.15)	475/449	0.67 (0.56–0.81)
Baby aspirin only	99/88	1.01 (0.72–1.42)	184/165	0.68 (0.52–0.87)
Other NSAIDs only	69/78	0.81 (0.58–1.18)	209/179	0.75 (0.59–0.96)
Both	23/30	0.68 (0.38–1.21)	82/105	0.47 (0.33–0.65)
Duration of regular use (yrs)
Non-users	382/340	1.00 (ref.)	685/472	1.00 (ref.)
Ever-users
≤4	72/80	0.79 (0.55–1.14)	164/171	0.61 (0.47–0.79)
5–9	64/65	0.94 (0.63–1.38)	128/125	0.64 (0.47–0.84)
≥10	55/51	1.00 (0.65–1.53)	183/153	0.77 (0.59–0.99)

^aAdjusted for age, race, education, household income, personal history of benign breast disease, first-degree family history of breast cancer, menopausal status, history of live birth, age at first live birth, use of hormone replacement therapy, regular exercise, alcohol consumption, and cigarette smoking status.

^bTest for interaction between regular use of any NSAIDs (non-users and ever-users) and BMI (< 25 kg/m² and ≥ 25 kg/ m²); P=0.023.