Table 3.
All women | BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | ||
---|---|---|---|---|
Cases/controls | OR (95% CI)a | Cases/controls | OR (95% CIa) | |
Regular use of any NSAIDsb | ||||
Non-users | 698/722 | 1.00 (ref.) | 1117/817 | 1.00 (ref.) |
Ever-users | 262/265 | 0.95 (0.77–1.17) | 593/553 | 0.71 (0.60–0.83) |
Baby aspirin only | 116/105 | 0.99 (0.73–1.34) | 219/184 | 0.74 (0.59–0.94) |
Other NSAIDs only | 120/128 | 0.93 (0.70–1.23) | 287/255 | 0.75 (0.61–0.92) |
Both | 26/32 | 0.73 (0.42–1.26) | 87/114 | 0.45 (0.33–0.62) |
Duration of any NSAIDs use (yrs) | ||||
Non-users | 698/722 | 1.00 (ref.) | 1117/817 | 1.00 (ref.) |
Ever-users | ||||
≤4 | 106/110 | 0.92 (0.68–1.23) | 208/227 | 0.62 (0.50–0.78) |
5–9 | 83/83 | 0.97 (0.70–1.36) | 166/151 | 0.72 (0.56–0.92) |
≥10 | 73/72 | 0.98 (0.68–1.40) | 219/175 | 0.81 (0.64–1.02) |
Postmenopausal women | BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | ||
Cases/controls | OR (95% CI)a | Cases/controls | OR (95% CI)a | |
Regular use of any NSAIDs | ||||
Non-users | 382/340 | 1.00 (ref.) | 685/472 | 1.00 (ref.) |
Ever-users | 191/196 | 0.89 (0.69–1.15) | 475/449 | 0.67 (0.56–0.81) |
Baby aspirin only | 99/88 | 1.01 (0.72–1.42) | 184/165 | 0.68 (0.52–0.87) |
Other NSAIDs only | 69/78 | 0.81 (0.58–1.18) | 209/179 | 0.75 (0.59–0.96) |
Both | 23/30 | 0.68 (0.38–1.21) | 82/105 | 0.47 (0.33–0.65) |
Duration of regular use (yrs) | ||||
Non-users | 382/340 | 1.00 (ref.) | 685/472 | 1.00 (ref.) |
Ever-users | ||||
≤4 | 72/80 | 0.79 (0.55–1.14) | 164/171 | 0.61 (0.47–0.79) |
5–9 | 64/65 | 0.94 (0.63–1.38) | 128/125 | 0.64 (0.47–0.84) |
≥10 | 55/51 | 1.00 (0.65–1.53) | 183/153 | 0.77 (0.59–0.99) |
Adjusted for age, race, education, household income, personal history of benign breast disease, first-degree family history of breast cancer, menopausal status, history of live birth, age at first live birth, use of hormone replacement therapy, regular exercise, alcohol consumption, and cigarette smoking status.
Test for interaction between regular use of any NSAIDs (non-users and ever-users) and BMI (< 25 kg/m2 and ≥ 25 kg/ m2); P=0.023.