Table 1.

Impact of arsenic exposure on CD1 mice until weaning

		Group (ppb):
Measurements		Control	50	500	5000
Dams Used to Make	n =	12	11	11	11
Groups on Day 21a
Maternal Body Weights (g)	n =	12	11	11	11
Gestation Day 10		35.0 ± 1.2	35.3 ± 1.1	35.4 ± 0.8	34.7 ± 0.9
Day 14		45.1 ± 1.5	44.9 ± 1.5	44.7 ± 1.2	44.9 ± 0.7
Day 18		59.8 ± 2.0	57.4 ± 3.8	60.4 ± 1.8	61.6 ± 1.1
Dam Water Consumptionb	n =	9	11	10	8
Gestation Day 16–8 (ml/dam/d)		12.6 ± 0.8	13.8 ± 1.0	13.8 ± 0.8	12.2 ± 0.7
Newborns/Litter at Birthc	n =	12	11	11	11
		12.3 ± 2.5	12.7 ± 0.8	12.2 ± 0.7	13.2 ± 0.5
Newborn Body Weight (g)c	n =	12	11	11	11
		1.73 ± 0.03	1.78 ± 0.05	1.81 ± 0.04	1.74 ± 0.05
Offspring Body weights (g)
Males Day 21	n =	10	10	11	11
		15.3 ± 0.5	16.3 ± 0.5	14.9 ± 0.5	15.4 ± 0.5
Females Day 21	n =	12	11	10	10
		14.3 ± 0.4	15.4 ± 0.3	14.6 ± 0.5	14.6 ± 0.4

Arsenic was given continuously as sodium arsenite in the drinking water to breeding pairs (10 males, 20 females) prior to breeding for three weeks, to pregnant dams, to lactating dams after birth (day 0), and to then the offspring from weaning up to 2 years of age when the experiment was terminated (see Methods). Data are expressed as the mean ± SEM. No significant differences from control occurred (p > 0.05) in any of these metrics.

^aLitters used to constitute groups of original n = 40 groups of male or female offspring.

^bWater consumption data was based on slightly fewer dams than other metrics because water was released from the bottles by animals activity (stuffing bedding into water tube, etc.).

^cDay 0. All newborns were born alive.