Table 3.

Bronchiolo-alveolar tumors and proliferative lesions induced by whole life arsenic exposure in males

Lesion	Lesion bearing mice/ Total examined	Percent	p-value
Adenoma:
Control	5/36	14%	-
50 ppb	10/37	27%	0.184
500 ppb	14/37	38%	0.024*
5000 ppb	6/39	15%	0.415
trend p			0.233
Carcinoma
Control	3/36	8%	-
50 ppb	10/37	27%	0.037*
500 ppb	7/37	19%	0.112
5000 ppb	6/39	15%	0.166
trend p			0.487
Adenoma or Carcinoma
Control	8/36	22%	-
50 ppb	19/37	51%	0.023*
500 ppb	20/37	54%	0.005**
5000 ppb	11/39	28%	0.230
trend p			0.196
Multiple Lung Tumorsa
Control	1/36	3%	-
50 ppb	5/37	14%	-
500 ppb	2/37	5%	-
5000 ppb	1/39	3%	-
Alveolar Hyperplasia
Control	1/36	3%	-
50 ppb	4/37	11%	-
500 ppb	2/37	5%	-
5000 ppb	1/39	3%	-

Arsenic was given continuously in the drinking water throughout life. Sample size is the number of mice available for pathological analysis. Data are expressed as mice with a given lesion (% pathologically assessed). Groups were derived from 10 to 11 litters with original n = 40 individuals (see Table 1 for details). A single asterisk (*) indicates a significant difference from control at p < 0.05 while a double asterisk (**) indicates a significant difference from control at p < 0.01. Data analyses are adjusted for survival and litter effects.

^aOne mouse in each treatment group had both a lung carcinoma and an adenoma. This is counted as a single event in “Carcinoma or Adenoma” and an event in “Multiple Tumors”.