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Overview of Tlr4 nonsynonymous substitutions in Mmd and Mmm. Numbers above alignment indicate amino acid position. ECD, extracellular domain; TMD, transmembrane domain; ICD, intracellular domain; LBR, ligand-binding region; TIR, Toll/interleukin-1 domain. Distribution of individual haplotypes (=alleles) among sampled specimens is presented in Table S1.
