Table 1. CVD risk factors evaluated in the plasma of SHROB and WKY rats (mean value and SEM)1.
| Category | Parameter | SHROB | WKY | ||
| SEM | SEM | ||||
| Physical measurements | Abdominal fat (% bw) | 6·7** | 0·4 | 4·3 | 0·2 |
| Plasma lipid profile | Total cholesterol (mM) | 8·3** | 1·2 | 3·3 | 0·2 |
| LDL-cholesterol (mM) | 0·4* | 0·1 | 0·1 | 0·004 | |
| HDL-cholesterol (mM) | 2·9* | 0·2 | 1·9 | 0·1 | |
| Total triglycerides (mM) | 40·0** | 0·0 | 5·6 | 1·1 | |
| Apo A1 (mg/dL) | 68·3* | 1·9 | 51·4 | 5·0 | |
| Apo B100 (mg/dL) | 205·4* | 18·7 | 126·8 | 5·3 | |
| Glycaemia | Glucose (mM) | 3.4 | 0.1 | 3.5 | 0.1 |
| Insulin (nM) | 1·0** | 0·2·9 | 0·3 | 0·1 | |
| HOMA index | 15·6** | 2·4 | 5·6 | 1·1 | |
| OGTT (AUC) | 5016·3 | 177·4 | 4494·0 | 122·8 | |
| Glycated Hb (%) | 6·8 | 0·4 | 6·4 | 0·4 | |
| Blood pressure | Systolic blood pressure (mmHg) | 193·2** | 12·5 | 121·0 | 2·2 |
| Diastolic blood pressure (mmHg) | 134·8** | 5·2 | 106·5 | 1·7 | |
| Endothelial dysfunction | VCAM-1 (µg/mL) | 2·7 | 0·3 | 3·4 | 0·6 |
| ICAM-1 (ng/mL) | 1·0** | 0·1 | 0·5 | 0·03 | |
| Inflammation | C reactive protein (pg/mL) | 285·9** | 22·0 | 172·8 | 14·4 |
| Thrombotic activity | PAI-1 (µg/mL) | 11·6** | 0·5 | 6·4 | 0·3 |
1
SHROB, Spontaneously Hypertensive Obese; WKY, Wistar Kyoto; OGTT, oral glucose tolerance test; VCAM-1, vascular cell adhesion molecule-1; ICAM-1, intercellular adhesion molecule-1; PAI-1, plasminogen activator inhibitor-1.
Statistically significant differences between the samples are indicated by * (P<0.05), ** (P<0.01) and *** (P<0.001).