Table 2. Experimental designs used for the animal studies.

Experimental animals	Group	Number of animals	Vaccine	Route	Dosage (µg)	Dose	Time-point for sera collection
Mice	1	10	PPRV-H VLP	S.C.	10	2 doses, 4 weeks apart	1 week before immunization, 3 weeks after primary and booster immunization.
	2	10	PPRV-H VLP	S.C.	40	2 doses, 4 weeks apart
	3	10	PPRV-F VLP	S.C.	10	2 doses, 4 weeks apart
	4	10	PPRV-F VLP	S.C.	40	2 doses, 4 weeks apart
	5	10	PPRV	S.C.	10	2 doses, 4 weeks apart
	6	10	PPRV	S.C.	40	2 doses, 4 weeks apart
	7	10	PBS	S.C.	/	2 doses, 4 weeks apart
Goats	1	5	PPRV-H VLP	S.C.	300	2 doses, 3 weeks apart	2 week before immunization, 3 weeks post-primary inoculation and 2,4,8, or 12 weeks post-booster inoculation.
	2	5	PPRV-F VLP	S.C.	300	2 doses, 3 weeks apart
	3	5	PPRV	S.C.	105.5TCID50	2 doses, 3 weeks apart
	4	5	PBS	S.C.	/	2 doses, 3 weeks apart

PBS  =  phosphate-buffered saline; PPRV  =  Peste des petits ruminants virus; S.C.  =  subcutaneous, TCID₅₀  = 50% tissue culture infective dose; VLP  =  virus-like particles.