Table 1. Main characteristics of the 83 study patients at ICU admission.
Median [IQR] or N (%) | |
Demographics | |
Age in years | 61.7 [48.4–74.5] |
Male | 56 (67.5%) |
Current smoker | 64 (77%) |
Known cardiovascular disease | 43 (51.8%) |
Poor chronic health status (Performance status ≥2) | 31 (32.4%) |
Exposure to pneumotoxic drugs | 30 (36.1%) |
Clinical presentation | |
Days from respiratory symptom onset to ICU admission | 11 [5]–[28] |
Crackles at chest auscultation | 76 (91.6%) |
Shock | 42 (50.6%) |
Acute kidney injury | 42 (50.6%) |
Significant proteinuria | 33 (45.2%) |
Skin rash | 25 (30.1%) |
Arthralgia | 11 (13.3%) |
ILD subgroups | |
Toxic | 22 (26.5%) |
Drug-induced ILD/Pneumoconiosis | 14/3 |
Radiation pneumonitis/Hypersensitivity pneumonitis | 2/3 |
Connective tissue diseases | 28 (33.7%) |
Rheumatoid arthritis | 5/28 |
Scleroderma | 6/28 |
Polymyositis/dermatomyositis | 2/28 |
Primary Sjogren’s syndrome | 3/28 |
Mixed connective tissue disease | 5/28 |
Antisynthetase syndrome | 2/28 |
Systemic lupus erythematosus/antiphospholipid syndrome | 2/28 |
Miscellaneous | 3/28 |
Idiopathic interstitial pneumonia (acute ILD) | 19 (22.8%) |
Cryptogenic organising pneumonia | 7 |
Acute interstitial pneumonia | 8 |
Lymphocytic interstitial pneumonia | 2 |
Idiopathic acute eosinophilic pneumonia | 2 |
Acute exacerbation of chronic idiopathic ILD | 17 (20.5%) |
Idiopathic pulmonary fibrosis (IPF) | 9 |
Chronic idiopathic interstitial lung disease (other than IPF) | 8 |
Langerhans cell histiocytosis | 2 (2.4%) |
Abbreviations: RV, right ventricular; ILD, interstitial lung disease.