Table 4. Determinants of hospital mortality.

	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.03 (1–1.06)	0.03
ILD not diagnosed previously	0.43 (0.18–1.06)	0.07
ECOG Performance status ≥2	2.01 (0.81–4.99)	0.13
Pre-capillary pulmonary hypertension	5.45 (2.04–14.59)	<0.001	4.55 (1.20–17.33)	p≤0.04
CT findings
CT micronodules	0.13 (0.02–1.12)	0.06
CT traction bronchiectasis/honeycombing	5.82 (1.95–17.32)	0.001	7.68 (1.78–33.22)	p≤0.01
Respiratory SOFA subscore	1.96 (1.19–3.21)	0.007
SOFA score	1.19 (1.05–1.35)	0.006
Shock	6.70 (2.49–18.08)	<0.001
Acute kidney injury	5.23 (2–13.69)	<0.001	10.60 (2.25–49.97)	p≤0.01
ILD aetiology
Connective tissue disease	1 (ref)
Idiopathic interstitial pneumonia (acute ILD)	0.71(0.18–2.84)	0.63
Acute exacerbation of chronic idiopathic ILD	4.17 (1.13–15.33)	0.03
Toxic	3.33 (1.01–10.97)	0.05
Ventilatory support
High flow oxygen	1 (ref)
Non-invasive ventilation alone	4.75 (0.72–31.40)	0.11
Non-invasive ventilation followed by intubation	17.4 (2.98–101.60)	<0.01
First line invasive mechanical ventilation	10.1 (2.02–50.40)	<0.01
High dose corticosteroid response
No high dose therapy	1 (ref)
High dose therapy with no response	34.36 (1.53–774)	<0.01
High dose therapy with response	0.11 (0.02–0.55)	<0.01

Abbreviations : OR, odds ratio; 95%CI, 95% confidence interval; ILD, interstitial lung disease; ECOG, Eastern Cooperative Oncology Group (the performance score can range from 0 [fully active] to 5 [dead]); CT, computed tomography of the chest; SOFA, Sequential Organ Function Assessment score.