Table 1. The effects of celastrol on secretions of cytokines and chemokines in ATRA-induced NB4 cells.

		Groups (n = 3)
		Control	Celastrol	ATRA	ATRA+Celastrol
IL-1β	24 h	2.7±0.9	2.4±0.8	2.4±0.7	2.6±0.6
(pg/mL)	48 h	6.4±1.0	4.3±1.2	8.3±0.9	4.4±0.8*
	96 h	6.4±1.0	6.4±2.0	31.6±2.6	22.5±3*
TNF-α	24 h	12.8±0.8	13.1±0.5	7.9±0.4	8.9±0.8
(pg/mL)	48 h	19.7±1.0	17.1±1.1	17.5±1.2	13.1±1.3
	96 h	40.7±2.3	36.1±2.1	648.9±34.0	365.1±23.0**
IL-8	24 h	978.4±18.1	1135.4±160.6	1135.4±320.7	1135.4±242.8
(pg/mL)	48 h	2594.5±89.9	3578.5±256.2	22306.5±783.1	19186.6±543.2
	96 h	1441.6±22.6	1800.5±390.4	27395.1±916.9	27156.1±256.3
MCP-1	24 h	ND	ND	ND	ND
(pg/mL)	48 h	ND	ND	ND	ND
	96 h	908.0±31.2	784.6±22.3	56339.6±1687.3	56206.2±1965.4

Note: * and ** represent P<0.05 and P<0.01, respectively, when compared with DMSO control; ND means ‘not detected’.