Figure 1. Sequence alignment of peptide ligands targeting the Mdm2 N-terminal domain.

The critical interacting residues (F19, W23 and L26) in the p53 wild-type peptide and conserved in the indicated stapled peptides are shaded. The staple tethering site is denoted by ‘X’ and chemical structure of the staple moiety (adapted from [18]) is shown below.