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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Immunol. 2014 Mar 26;192(9):4074–4082. doi: 10.4049/jimmunol.1301264

Table 1.

Maternal immune response against CM and associated left-side structural congenital cardiac abnormalities in the progeny.

Fetal Litter Litter Size Total Maternal
Antibody
Burden		 Progeny with
Heart Defects
% (#affected)		 LV Cavity
Hypoplasia %
(#affected)		 Loss of Normal
Valve Structure
% (#affected)		 Severely
Increased LV
Myocardial Wall
Thickness %
(#affected)		 Moderately
Increased LV
Myocardial Wall
Thickness
% (#affected)
CM4 11 3.2 ×105 36% (4) 27% (3) 36% (4) 9% (1) 18% (2)
CM5 12 4.0 ×105 8% (1) 8% (1) 8% (1) 8% (1) 0
CM7 8 2.6 ×105 25% (2) 25% (2) 25% (2) 25% (2) 0
CM8 9 7.3 × 105 67% (6) 55% (5) 44% (4) 55% (5) 11% (1)
CM10 7 2.3 ×105 29% (2) 29% (2) 14% (1) 29% (2) 0
C1 13 <100 0% (0) 0 0 0 0
C2 3 <100 0% (0) 0 0 0 0
C3 3 <100 0% (0) 0 0 0 0

Footnotes: The total maternal antibody burden was calculated using area under the curve of the maternal antibody titer graph (Fig.1). The values given are the mean ± s.e.m. of each liter. Neither maternal nor fetal adjuvant-injected control animals (C1-3) had elevated anti-CM antibody titers.

Abbreviations: CM=cardiac myosin immunized; C=adjuvant injected controls; D=day.