Table 1.
Physicochemical properties, drug-encapsulation efficiency (EE), and drug-loading capacity of GME-encapsulated nanoparticles
| Formulation | Diameter (nm)a | PDIb | ζ-potential (mV)c | EE (%) | Loading (%) |
|---|---|---|---|---|---|
| GME-EC | 253.3±8.6 | 0.05±0.01 | −30.9±0.4 | 86.2±3.9 | 43.1±1.9 |
| GME-EC/MC | 249.2±13.1 | 0.07±0.04 | −11.7±0.5 | 87.5±4.1 | 43.5±2.1 |
| C-EC | 239.9±16.9 | 0.12±0.04 | −21.7±1.9 | – | – |
| C-EC/MC | 233.8±8.1 | 0.12±0.02 | −18.8±2.2 | – | – |
Notes:
Diameter (number mean) measured by dynamic light scattering; data represent the average of three independent experiments ± SD
the polydispersity index (PDI), measured by dynamic light scattering, represents relative variance in particle-size distribution; a PDI of 1 indicates a large distribution of particle size, whereas a PDI of 0 indicates a monodisperse size distribution; data represent the average of three independent experiments ± SD
measured at pH 7.1; data represent the average of three independent experiments ± SD.
Abbreviations: GME, Garcinia mangostana Linn extract; EC, ethyl cellulose; MC, methyl cellulose; SD, standard deviation; C, coumarin 6.