Figure 3. D261 suppresses NSCLC growth in vivo. Female BALB/c nude mice with NCI-H460 xenografts were injected intravenously with D261 or DMSO daily for 3 wk. Body weight of mice (A) and tumor volume (B) were recorded every 3 d. (C and D) Tumor measurement was made after mice were sacrificed. (E) Midkine (MK) expression of the tumor tissue was determined by qRT-PCR. Data are shown as mean ± SEM (n = 7). *P < 0.05, **P < 0.01, compared with DMSO control.