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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Gut. 2007 Oct 26;57(3):384–404. doi: 10.1136/gut.2006.101675

Figure 1.

Figure 1

General strategy in irritable bowel syndrome (IBS) drug discovery and development. The schematic illustrates the vertical progression from the symptom complex of IBS to target identification in animal cells. For each step the current approach is shown in the left portion of the boxes. In the right portion of each box, suggested modifications to the current approach are shown. The current approach is lengthy, expensive and based on poor correlations between the individual steps. GI, gastrointestinal.