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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: N Engl J Med. 2013 Nov 27;369(24):2275–2277. doi: 10.1056/NEJMp1311405

Table 1.

Selected Recent Dementia Epidemic Studies

Study/
Authors
Outcome Data
Source
Key Findings Factors
Manton et al.
(USA)
Severe
cognitive
impairment
prevalence
National long-
term care survey
interviews 1982–
1999
Decline in dementia
prevalence in > 65 year
olds: 5.7% to 2.9%
Higher education,
decline in strokes
Langa et al.
(USA)
Cognitive
impairment
prevalence
US Health and
Retirement Study
Cognitive impairment in
≥70-year-olds:
12.2% in 1993
8.7% in 2002
Education;
combination of
medical, lifestyle,
demographic, and
social factors
Schrijvers et al.
(Rotterdam)
Dementia
incidence
Population-based
cohort aged 55+
in 1990 extended
in 2000
Incidence rate ratios =
6.56 per 1,000 person
years in 1990 vs 4.92 in
2000.
Education,
reduction in
vascular risk, decline
in strokes
Qiu et al.
(Stockholm)
DSMIII-R
dementia
prevalence
Cross-sectional
survey of 75-
year-olds, 1987–
89 and 2001–04
Age- and sex-
standardized dementia
prevalence: 17.5% in
1987–89 and 17.9% in
2001–04.

Lower death hazard rate
in later cohort suggests
decreased dementia
incidence
Favorable changes
in risk factors
especially vascular
risk, and healthier
lifestyles
Matthews et al.
(CFAS I and II)
(England)
Dementia
prevalence in
3 regions
Survey
interviews of
≥65-year-olds,
1989–94 and
2008–11
Dementia prevalence
8.3% in CFAS I and 6.5%
in CFAS II
Higher education,
better prevention of
vascular disease