Table 1.

Effects of drugs and IBS on brain activity. Group×drug interactions (individual group effects needed for interpretation).

		Cluster p	k	Voxel p (FWE)	T	X	y	z
PLA>YOH; HC>IBS
Dorsal brainstem	L	0.066	13	0.060	3.05	−8	−30	−22
	R	NS		NS
Amygdala	L	NS		NS
	R	0.038	32	0.001 *	4.94	28	−6	−16
Subgenual ACC	L	0.028	60	0.005	4.22	−2	24	−10
	R	0.031	50	0.010	3.88	8	42	−10
Pregenual ACC	L	0.058	48	0.046	3.50	−6	36	14
	R	NS		NS
Posterior insula	L	NS		NS
	R	0.087	38	0.069	3.41	38	0	−10
HC:PIA>YOH
Dorsal brainstem	L	0.035	42	0.037	3.29	−8	−30	−24
	R	NS		NS
Amygdala	L	NS		NS
	R	0.026	51	<0.0005 *	5.07	28	−6	−16
Subgenual ACC	L	0.027	62	0.005	4.21	−2	24	−10
	R	0.019	79	0.002 *	4.44	10	42	−10
Pregenual ACC	L	0.001*	376	0.001 *	5.13	−4	38	14
	R	0.053	51	0.055	3.40	16	44	14
Posterior insula	L	0.081	53	0.055	3.62	−38	−16	−6
	R	0.050	70	0.050	3.56	38	4	16
CLO>PIA, IBS>HC
Subgenual ACC	L	0.045	34	0.008	4.01	−4	24	−8
	R	NS		NS
IBS: CLO>PLA
Subgenual ACC	L	0.023	73	0.001 *	4.74	−4	24	−10
	R	0.028	55	0.007	4.01	10	40	−12

^*significant after Bonferroni correction, 0.05/16 = 0.0031, k = # of voxels. Con = control, PLA = placebo, YOH = yohimbine, FWE = family wise error corrected, ACC = anterior cingulate cortex, PFC = prefrontal cortex, NS=p>0.1.