Table 2.

Group differences in covariation of regional activity with anxiety.

		Cluster p	k	Voxel p (FWE)	T	X	Y	z
HC>IBS
Dorsal brainstem	L	0.007	142	<0.0005 ^*	6.33	−2	−36	−18
	R	0.036	41	0.001 ^*	4.75	4	−34	−20
Amygdala	L	0.070	10	0.006	4.09	−18	0	−18
	R	0.003 ^*	193	<0.0005 ^*	5.68	28	4	−22
Subgenual ACC	L	0.016	92	<0.0005 ^*	5.34	−4	28	−12
	R	NS		NS
Pregenual ACC	L	0.046	60	0.031	3.76	−10	36	16
	R	NS	16	0.005	4.54	14	32	22
Anterior insula	L	NS		NS
	R	<0.0005 ^*	547	<0.0005 ^*	6.83	36	20	8
Posterior insula	L	NS	11	0.081	3.50	−40	−22	−4
	R	0.000 ^*	554	<0.0005 ^*	7.51	36	−22	20
Ventrolateral PFC	L	NS		NS
	R	<0.0005 ^*	991	<0.0005 ^*	7.86	42	28	10
Positive covariation in the HC group
Dorsal brainstem	L	0.010	102	<0.0005 ^*	7.73	−2	−36	−18
	R	0.043	31	<0.0005 ^*	7.23	16	−22	−6
Amygdala	L	0.021	58	0.002 ^*	5.58	−16	−2	−20
	R	0.002 ^*	218	<0.0005 ^*	7.85	26	2	−24
Subgenual ACC	L	0.005	146	<0.0005 ^*	7.24	−4	28	−12
	R	NS		NS
Pregenual ACC	L	0.037	66	0.023	4.60	−12	36	18
	R	NS		NS
Anterior insula	L	NS		NS
	R	0.004	208	<0.0005 ^*	8.32	36	20	12
Posterior insula	L	NS		NS
	R	0.003 ^*	236	<0.0005 ^*	12.02	32	−18	8
Ventrolateral PFC	L	NS		NS
	R	<0.0005 ^*	974	<0.0005 ^*	9.18	40	26	10
Negative covariation in the IBS group
Posterior insula	L	NS		NS
	R	NS	12	0.037	4.47	48	−8	0
IBS>HC
MCC	L	0.009	200	<0.0005 ^*	5.79	−6	16	42
	R	NS	23	0.020	4.14	12	26	38
Anterior insula	L	<0.0005 ^*	489	<0.0005 ^*	8.25	−36	30	−8
	R	NS		NS
Posterior insula	L	0.007	229	0.001 ^*	5.58	−44	−20	12
	R	NS		NS
Ventrolateral PFC	L	<0.0005 ^*	1204	<0.0005 ^*	11.03	−36	36	12
	R	NS		NS
Negative covariation in the HC group
MCC	L	0.008	179	0.005	6.26	−10	18	42
	R	0.057	61	0.021	6.10	12	20	40
Anterior insula	L	<0.0005 ^*	678	<0.0005 ^*	9.05	−36	30	−8
	R	NS		NS
Posterior insula	L	<0.0005 ^*	553	<0.0005 ^*	7.82	−42	−22	20
	R	NS		NS
Ventrolateral PFC	L	<0.0005 ^*	1299	<0.0005 ^*	9.97	−38	46	−4
	R	NS		NS

significant after Bonferroni correction, 0.05/16 = 0.0031, k = # of voxels.

FWE = family wise error corrected, ACC = anterior cingulate cortex, PFC = prefrontal cortex, and MCC = mid cingulate cortex.