Table 3.

Covariation within a limbic stress circuit (amygdala, dorsal brainstem, 3 ACC regions).

		Cluster p	k	Voxel p (FWE)	T	X	y	z
Covariation with subgemal ACC positive covariation
Amygdala	L	0.041	30	0.024	3.49	−18	−6	−16
	R	0.020	66	0.031	3.37	26	−8	−18
Pregenual ACC	L	NS		NS
	R	0.026	106	0.023	3.98	8	46	−2
IBS>HC
Dorsal brainstem	L	NS		NS
	R	0.056	21	0.012	3.83	4	−34	−18
MCC	L	NS		NS
	R	0.023	128	0.030	3.94	4	22	22
Positive covariation in the IBS group
Dorsal brainstem	L	NS		NS
	R	0.046	30	0.008	4.02	4	−34	−18
Amygdala	L	0.037	35	0.019	3.60	−18	−6	−14
	R	0.037	33	0.019	3.60	22	0	−24
Pregenual ACC	L	NS		NS
	R	0.041	77	0.009	4.40	12	56	−2
Negative covariation in the HC group
MCC	L	NS		NS
	R	0.030	110	0.050	3.70	2	34	32
Covariation with amygdala positive covariation (main effect)
Dorsal brainstem	L	0.054	21	0.036	3.34	−6	−34	−14
	R	NS		NS
Subgenual ACC	L	0.016	92	0.008	4.09	−4	26	−12
	R	0.005 *	173	0.002 *	4.72	10	42	−8
Pregenual ACC	L	NS		NS
	R	0.014	153	0.007	4.49	6	46	0
IBS>HC group
MCC	L	NS		NS
	R	0.026	120	0.011	4.40	6	26	30
Positive covariation in the IBS group
Subgenual ACC	L	0.019	83	0.005 *	4.32	−4	26	−10
	R	0.027	57	0.013	3.81	10	42	−10
Negative covariation in the HC group
MCC	L	NS		NS
	R	0.034	100	0.023	4.07	8	26	32

^*significant after Bonferroni correction, 0.05/8 ROIs = 0.0063, k = # of voxels. Pla = placebo, FWE = family wise error corrected, ACC = anterior cingulate cortex, and MCC = mid cingulate cortex.