Table 3.
MicroRNAs deregulated in hepatocellular carcinoma
| miRNAs | Expression in HCC | Target | Involvement in cellular processes |
| miR-199 | Down | Met, mTOR, PAK4, DDR1, caveolin-2 | Proliferation, autophagy, metastasis, invasion; autophagy, drug resistance; cell growth[95] |
| miR-449 | Down | c-Met | Proliferation; apoptosis[97] |
| miR-122 | Down | Bcl-w, ADAM-1, Wnt-1 | Apoptosis; metastasis; angiogenesis[100-102] |
| miR-34a | Down | c-Met; CCL22 | Metastasis[103] |
| miR-200a | Down | HDAC4 | Proliferation; metastasis[104] |
| miRs-let-7a, -7b, -7c, -7d, -7f-1 | Down | Caspase-3, HMGA2, C-myc, Bcl-xl | Proliferation, apoptosis[112] |
| miR-125a, -125b | Down | MMP11, SIRT7, VEGF-A, LIN28B2, Bcl-2, Mcl-1, Bcl-w | Angiogenesis, apoptosis, metastasis, proliferation[115,116] |
| miR-29 | Down | SPARC | Proliferation[114] |
| miR-224 | Up | RKIP; CDC42; CDH1; PAK2; BCL-2; MAPK1; API-5 | Metastasis; proliferation; apoptosis[113] |
| miR-519d | Up | CDKN1A/p21; PTEN; AKT3; TIMP2 | Proliferation; invasion; apoptosis[109] |
| miR-216a | Up | TSLC1,PTEN | Tumorigenesis[107] |
| miR-148a | Up | PTEN | Tumorigenesis[108] |
| miR-21 | Up | PTEN, RhoB, PDCD4 | Drug resistance, metastasis[105,106] |
| miR-221 | Up | Bmf, DDIT4, Arnt, CDKN1B/p27, CDKN1C/p57 | Angiogenesis, apoptosis, proliferation[98,99] |
HCC: Hepatocellular carcinoma.