. 2014 Aug 14;20(30):10368–10382. doi: 10.3748/wjg.v20.i30.10368

Table 2.

Anti-Helicobacter pylori activity of medicinal plant extracts and fractions

Plant	Test sample	MIC/MBC	Ref.
Strong activity (MIC: < 10 μg/mL)
Impatiens balsamina L.	Pod acetone/95% ethanol/	MIC: 0.625-2.5 μg/mL	Wang et al[52]
Impatiens balsamina L.	ethyl acetate extracts	MBC: 1.25-2.5 μg/mL	Wang et al[52]
Strong-moderate acticity (MIC: 10-100 μg/mL)
Persea americana, Annona cherimola, Guaiacum coulteri, Moussonia deppeana	Methanol extract	MIC: 7.5-15.6 μg/mL	Castillo-Juárez et al[53]
Myristica fragrans (seed), Rosmarinus officinalis (rosemary leaf )	Methanol extract	MIC: 12.5-25 μg/mL	Mahady et al[54]
Curcuma amada Roxb., Mallotus phillipinesis (Lam) Muell., Myrisctica fragrans Houtt., Psoralea corylifolia L.	70% Ethanol extract	MIC: 15.6-62.5 μg/mL	Zaidi et al[55]
Achillea millefolium, Foeniculum vulgare (seed), Passiflora incarnata (herb), Origanum majorana (herb) and a (1:1) combination of Curcuma longa (root), ginger rhizome	Methanol extract	MIC: 50 μg/mL	Mahady et al[54]
Carum carvi (seed), Elettaria cardamomum (seed), Gentiana lutea (roots), Juniper communis (berry), Lavandula angustifolia (flowers), Melissa officinalis (leaves), Mentha piperita (leaves), Pimpinella anisum (seed)	Methanol extract	MIC: 100 μg/mL	Mahady et al[54]
Abrus cantoniensis, Saussurea lappa, Eugenia caryophyllata	Ethanol extract	MIC: 40 μg/mL	Li et al[56]
Hippophae rhamnoides, Fritillaria thunbergii, Magnolia officinalis, Schisandra chinensis, Corydalis yanhusuo, Citrus reticulata, Bupleurum chinense, Ligusticum chuanxiong	Ethanol extract	MIC: 60 μg/mL	Li et al[56]
Myroxylon peruiferum	Methanol extract	MIC: 62.5 μg/mL	Ohsaki et al[57]
Weak-moderate acticity (MIC: 100-1000 μg/mL)
Aristolochia pauciner6is	Rhizome/leave fraction	MIC: 4-128 μg/mL	Gadhi et al[58]
Cistus laurifolius, Spartium junceum, Cedrus libani, solstitialis, Momordica charantia, Sambucus ebulus, Hypericum perforatum	Solvent extract and hexane fraction	MIC: 1.95-250 μg/mL	Yeşilada et al[59]
Larrea divaricate Cav (leaves and tender branches)	Aqueous extract	MIC: 40-100 μg/mL	Stege et al[60]
Acacia nilotica (L.) Delile, Calotropis procera (Aiton)	Methanol/acetone extract	MIC: 8-256 μg/mL	Amin et al[61]
W.T. Aiton, Fagonia arabica L., Adhatoda vasica Nees, Casuarina equisetifolia L.	Methanol/acetone extract	MIC: 8-256 μg/mL	Amin et al[61]
Zingiber officinale	95% Ethanol extract	MIC: 10-160 μg/mL	Nostro et al[62]
Tephrosia purpurea (Linn.) Pers.	Methanol extract and fraction	MIC: 25-400 μg/mL	Chinniah et al[63]
Terminalia macroptera (root)	Root solvent fraction	MIC: 100-200 μg/mL	Silva et al[64]
Black myrobalan (Teminalia chebula Retz)	Water extract	MIC: 125 μg/mL	Malekzadeh et al[65]
Black myrobalan (Teminalia chebula Retz)	Water extract	MBC: 150 μg/mL	Malekzadeh et al[65]
Rubus ulmifolius leaves	Ethyl acetate/methanol	MIC: 134-270 μg/mL	Martinia et al[66]
Amphipterygium adstringens	Bark petroleum ether fraction	MIC: 160 μg/mL	Castillo-Juárez et al[67]
Lycopodium cernuum	Hexane fraction	MIC: 16-1000 μg/mL	Ndip et al[68]
Lycopodium cernuum	Hexane fraction	MBC: 125-1000 μg/mL	Ndip et al[68]
Ageratum conyzoides, Scleria striatinux, Lycopodium cernua	Methanol extract	MIC: 63-1000 μg/mL	Ndip et al[69]
	Methanol extract	MBC: 195-15000 μg/mL	Ndip et al[69]
Sclerocarya birrea	Acetone/aqueous stem bark extract	MIC: 80-2500 μg/mL	Njume et al[70]
Including Artemisia ludoviciana subsp.mexicana 43 plants	Methanol/aqueous extract	MIC: 312-500 μg/mL	Castillo-Juárez et al[53]
Pteleopsis suberosa	Stem bark methanol extract	MIC: 313-500 μg/mL	Germanò et al[71]
Ageratum conyzoides, Scleria striatinux, Lycopodium cernua	Methanol extract	MIC: 32-1000 μg/mL	Ndip et al[69]
Including Cuminum cyminum L., Cynara scolymus L., Origanum vulgare L. 17 plants	Ethanol extracts	MIC: 600-10000 μg/mL	Nostro et al[72]
Allium sativum	Aqueous extract	MIC: 2000-5000 μg/mL	Cellini et al[73]
Weak acticity (MIC: > 1000 μg/mL)
Mentha × piperita, Peppermint Oil, Origanum vulgare, Pimpinella anisum, Aniseed Oil, Syzygium aromaticum	Essential oil	IC₅₀: 160-1460 μg/mL	Cwikla et al[74]
Chamomila recutita L., Ilex paraguariensis A. St.-Hil.	96% Ethanol extract	MIC: < 625-1250 μg/mL	Cogo et al[75]
Allium ascalonicum Linn. (leaf)	Methanol extract	MIC: 625- 1250 μg/mL	Bolanle et al[76]
Sclerocarya birrea	Stem bark acetone/aqueous extracts	MIC₉₀: 60-2500 μg/mL	Njume et al[70]
Punica granatum, Quercus infectoria	Ethanol extract	MIC: 160-> 2500 μg/mL	Voravuthikunchai et al[77]
Mentha × piperita, Peppermint Oil, Origanum vulgare, Pimpinella anisum, Aniseed Oil, Syzygium aromaticum	Essential oil	IC₅₀: 160-1460 μg/mL	Cwikla et al[74]
Including Anthemis melanolepis 13 plants	70% Methanol extract	MIC: 625-5000 μg/mL	Stamatis et al[78]
Including Cuminum cyminum L. 17 plants	Ethanol extract	MIC: 75-10000 μg/mL	Nostro et al[72]
Plumbago zeylanica L.	Acetone extract	MIC: 320-10240 μg/mL	Wang and Huang[79]
Plumbago zeylanica L.	Acetone extract	MBC: 5120-81920 μg/mL	Wang and Huang[79]
Anisomeles indica (L.) O. Kuntze, Alpinia speciosa (Wendl.) K. Schum., Bombax malabaricum DC., Paederia scandens (Lour.) Merr.	95% Ethanol extract	MIC: 640-10240 μg/mL	Wang and Huang[80]
Allium sativum	Aqueous extract	MIC: 0.1% (v/v)	Cellini et al[73]
Including Cymbopogon citratus (lemongrass) 13 plants	Essential oil		Ohno et al[81]

MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentration.