Table 3.
Adipokines and liver steatosis in chronic hepatitis C
|
With steatosis (n
= 10) |
Without steatosis (n
= 21) |
P value | |||
| Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
| SOCS3 | 6.553 (3.393-11.777) | 1.042-24.537 | 5.106 (2.095-8.713) | 0.5-17.95 | P > 0.05 |
| HOMA | 2.815 (1.99-4.84) | 1.25-9.67 | 1.995 (1.21-2.51) | 0.78-7.25 | P = 0.05 |
| Adiponectin (μg/mL) | 5.985 (4.83-7.23) | 3.55-8.43 | 8.37 (5.71-9.07) | 3.51-18.48 | P = 0.047 |
| Osteopontin (ng/mL) | 33.51 (15.52-49.12) | 5.33-59.15 | 24.7 (18.26-34.58) | 11.57-47.85 | P > 0.05 |
| Leptin (ng/mL) | 5.705 (3.04-17.2) | 2.34-54.65 | 3.825 (1.33-13.11) | 0.77-39.04 | P > 0.05 |
| Resistin (ng/mL) | 1.65 (1.42-1.84) | 1.17-2.36 | 1.51 (1.03-1.58) | 0.73-2.92 | P > 0.05 |
| Omentin (ng/mL) | 374.875 (332.79-483.33) | 227.99-757.34 | 393.92 (360.09-522.77) | 115.7-735.84 | P > 0.05 |
| Visfatin (ng/mL) | 2.465 (1.37-3.12) | 0.45-3.97 | 2.64 (1.17-4.08) | 0.53-9.37 | P > 0.05 |
Hepatic steatosis was related to increased HOMA-IR index (2.81 vs 1.99, P = 0.05) and reduced adiponectin level (5.96 vs 8.37, P = 0.04). SOCS-3: Suppressor of cytokine signaling 3; HOMA-IR: Homeostasis model assessment of insulin resistance; LQ: Lower quartile; UQ: Upper quartile.