Table 8.
Adipokines and single nucleotide polymorphisms of interleukin 28B in chronic hepatitis C
|
CC (n
= 6) |
TT/CT (n
= 25) |
P value | |||
| Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
| SOCS-3 | 11.52 (3.164-15.738) | 2.17-17.95 | 5.10 (1.75-8.713) | 0.5-24.537 | P > 0.05 |
| HCV viremia (IU/mL) | 1195000 (362000-3830000) | 112000-9850000 | 3780000 (799000-4290000) | 382000-7210000 | P > 0.05 |
| ALT (U/L) | 54 (43-83) | 23-339 | 45 (44-47) | 41-48 | P > 0.05 |
| HOMA | (1.02-3.99) | 0.78-5.66 | 2.44 (1.5-2.84) | 0.88-9.67 | P > 0.05 |
| Adiponectin (μg/mL) | 7.56 (6-8.37) | 5.33-9.07 | 6.35 (5.34-8.89) | 3.51-18.48 | P > 0.05 |
| Osteopontin (ng/mL) | 24.33 (22.18-32.98) | 13.14-34.58 | 29.94 (16.79-37.78) | 5.33-59.15 | P > 0.05 |
| Visfatin (ng/mL) | 2.64 (1.57-6.35) | 0.65-9.33 | 2.56 (1.13-5.69) | 0.45-9.37 | P > 0.05 |
| Leptin (ng/mL) | 13.11 (8.56-17.2) | 5.47-39.04 | 3.04 (1.69-11.94) | 0.77-54.65 | P > 0.05 |
| Omentin (ng/mL) | 367.16 (257.55-399.91) | 152.74-522.77 | 390.95 (341.39-536.18) | 115.7-757.34 | P > 0.05 |
| Resistin (ng/mL) | 1.17 (0.91-1.65) | 0.76-1.74 | 1.55 (1.205-1.83) | 0.73-2.92 | P > 0.05 |
The single nucleotide polymorphisms (SNPs) of IL28B (rs 12979860) were not associated with adipokine levels or HOMA-IR index. Genotypes of IL28B: CC and not CC (CT and TT); SOCS-3: Suppressor of cytokine signaling 3; HOMA-IR: Homeostasis model assessment of insulin resistance; ALT: Alanine aminotransferase; LQ: Lower quartile; UQ: Upper quartile.