Table 1. Examples of PMQC in Yeast and Mammalian Cells.

PM Protein	Misfolding Condition	Recognition Mechanism	Ubiquitin Ligase	Reference
Yeast
Ste2	ste2-3 allele (ts)	unknown	Rsp5	[16,17]
Can1	can1-ts allele	unknown	Rsp5	[17]
Pma1	pma1-10 allele	unknown	Rsp5	[57]
Gap1	low [sphingolipids]	unknown	Rsp5	[45]
Lyp1	heat stress	Art1 and Art2	Rsp5	[30]
Fur4	heat stress	Rsp5	Rsp5	[31]
Mammalian
CFTR	ΔF508 CFTR	Hsc70, Hsp90	CHIP	[18]
hERG	mutation, altered [K+]		CHIP	[22]
Kir2.1	unknown	unknown	unknown	[39]