Table 1.

Clinical, genetic, and epigenetic information on study participants.

Group	Sample	Sample type	Family history	Mutation	Pathological diagnosis	Sex	Age of onset (years)	Duration (months)	Trimethylated H3K9, H3K27, H3K79, H4K20		Number of cerebellum methylated CpG sites (/26)
									Frontal cortex	Cerebellum
c9FTD/c9ALS	1	ALS	no	C9orf72 repeat expansion	ALS/PA	F	61	33	yes	yes	0
	2	ALS	no	C9orf72 repeat expansion	ALS	M	56	26	yes	yes	1
	3	ALS	no	C9orf72 repeat expansion	ALS	M	52	76	yes	yes	0
	4	ALS	Cognitive impairments/dementia	C9orf72 repeat expansion	ALS	M	49	49	yes	yes	0
	5	FTD	Dementia	C9orf72 repeat expansion	FTLD-U/HpScl	M	67	98	yes	yes	16
	6	FTD	AD/FTD	C9orf72 repeat expansion	FTLD-U	M	70	28	yes	yes	0
	7	FTD	FTD	C9orf72 repeat expansion	FTLD-U	M	74	93	yes	yes	1
	8	FTD	no	C9orf72 repeat expansion	FTLD-U/HpScl/PA	M	62	131	yes	yes	0
	9	FTD	ALS/FTD/Neurodegeneration	C9orf72 repeat expansion	FTLD/MND/HpScl	M	<60	60	yes	yes	0
	10	FTD	Dementia Neurodegeneration	C9orf72 repeat expansion	FTLD-U/HpScl	M	68	71	yes	yes	0
FTD/ALS	1	ALS	no	unknown	ALS/PA	F	60	15	no	no	0
	2	ALS	no	unknown	ALS/heterotopia	M	45	58	no	no	0
	3	ALS	no	unknown	ALS	M	50	47	no	no	0
	4	ALS	no	unknown	ALS/SC	M	53	65	no	no	0
	5	FTD	Neurodegeneration	unknown	FTLD-U/HpScl/AGD	M	63	51	no	no	0
	6	FTD	no	unknown	FTLD-U/HpScl/AGD/VaD	M	73	105	no	no	0
	7	FTD	Neurodegeneration	unknown	FTLD-U/HpScl/PA/BLBD	M	74	45	no	no	0
	8	FTD	no	unknown	FTLD-U/VaD/AGD	M	65	18	no	no	0
	9	FTD	no	unknown	FTLD-U/Limbic gliosis	M	66	122	no	no	0
Disease controls	1	n/a	ET	unknown	PA/CVA	M	72	112	no	no	0
	2	n/a	no	unknown	PA/VaD	F	n/a	n/a	no	no	0
	3	n/a	ET	unknown	AGD/PA	F	82	22	no	no	0
	4	n/a	no	unknown	AGD/Fahr	M	72	50	no	no	0
	5	n/a	Dementia	n/a	Normal	F	64	9	no	no	1
	6	n/a	unavailable	unknown	VaD	M	63	79	no	no	2
	7	n/a	Neurodegeneration	unknown	VaD/HpScl	M	63	100	no	no	2
	8	n/a	ALS/dementia	unknown	VaD/SC	M	unknown	unknown	no	no	0

AD: Alzheimer's Disease, AGD: Argyrophilic Grain Disease, ALS: Amyotrophic Lateral Sclerosis, BLBD: Brainstem Lewy Body Disease, CVA: Cerebral Vascular Accident, ET: Essential Tremor, Fahr: Fahr's Syndrome, FTLD-U: Frontotemporal Lobar Degeneration with Ubiquitin inclusions, HpScl: Hippocampal Sclerosis, ILBD: Incidental Lewy Body Disease, MND: Motor Neuron Disease, PA: Pathological Aging, SC: Sydenham's chorea, VaD: Vascular Dementia. M: male, F: female, n/a: non-applicable.