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. Author manuscript; available in PMC: 2014 Aug 14.
Published in final edited form as: J Invest Dermatol. 2008 Oct 16;129(3):629–634. doi: 10.1038/jid.2008.297

Table 3.

Association test and meta-analysis of the three replicated markers with psoriasis risk in the fourth sample set and all case–control sample sets investigated

Gene SNP Sample set Case
Control
Allelic P1 OR (95%CI)2
11 12 22 Sum MAF 11 12 22 Sum MAF
ADAM33 rs5979803 SS1 98 243 117 458 0.479 105 217 136 458 0.466 0.287 1.05 (0.87–1.26)
SS2 126 220 147 493 0.479 101 237 154 492 0.446 0.074 1.14 (0.95–1.36)
SS3 105 240 137 482 0.467 82 208 136 426 0.437 0.099 1.12 (0.93–1.35)
SS4 119 292 181 592 0.448 41 93 87 221 0.396 0.031 1.23 (0.98–1.54)
SS1+2+3+4 448 995 582 2,025 0.467 329 755 513 1,597 0.442 0.0057 1.13 (1.02–1.24)
CDKAL1 rs6908425 SS1 21 135 309 465 0.190 26 150 281 457 0.221 0.052 0.82 (0.66–1.03)
SS2 18 147 327 492 0.186 23 175 294 492 0.225 0.017 0.78 (0.63–0.98)
SS3 18 179 285 482 0.223 26 130 270 426 0.214 0.686 1.05 (0.84–1.32)
SS4 14 177 397 588 0.174 13 65 144 222 0.205 0.077 0.81 (0.62–1.07)
SS1+2+3+4 71 638 1,318 2,027 0.192 88 520 989 1,597 0.218 0.010 0.87 (0.77–0.97)
UK4 46 360 773 1,179 0.192 165 1,018 1,749 2,932 0.230 1.52E–04 0.79 (0.70–0.89)
SS1+2+3+4+UK 117 998 2,091 3,206 0.192 253 1,538 2,738 4,529 0.226 1.57E–05 0.83 (0.76–0.90)
PTPN22 rs3789604 SS1 10 136 315 461 0.169 23 152 284 459 0.216 0.0057 0.74 (0.58–0.93)
SS2 21 161 311 493 0.206 17 177 298 492 0.214 0.321 0.94 (0.76–1.17)
SS3 15 140 327 482 0.176 14 135 277 426 0.191 0.205 0.90 (0.71–1.14)
SS4 14 159 379 552 0.169 13 52 154 219 0.178 0.341 0.94 (0.70–1.25)
SS1+2+3+4 60 596 1,332 1,988 0.180 67 516 1,013 1,596 0.204 0.016 0.87 (0.77–0.98)
UK5 23 199 613 835 0.147 84 765 1,621 2,470 0.189 9.94E–05 0.73 (0.63–0.86)
SS1+2+3+4+UK 83 795 1,945 2,823 0.170 151 1,281 2,634 4,066 0.195 3.45E–05 0.81 (0.74–0.89)
1

Calculated by χ2 method for individual sample sets and by Mantel Haenszel method for the combined sample sets; two sided for UK and SS1+2+3+4+UK and one sided for all other replication sample sets, individually or combined.

2

Calculated by χ2 method for individual sample sets and by Mantel Haenszel method for the combined sample sets.

3

Prior study used family-based samples; not included for meta-analysis.