Figure 3.

Computational deconvolution of cell-type-specific gene expression. A, Cell-type distribution heat map of canonical neural marker genes based on computational deconvolution of 10 RNA-Seq profiles from 10 murine proneural gliomas. The columns are the cell types used for deconvolution and the values are normalized across rows. Genes used to seed the deconvolution algorithm are underlined. B, Cell-type distribution heat map of RiboTag-enriched genes based on deconvolution of the profiles in A showing a strong enrichment in the OPC lineage, consistent with the glial progenitor origin of the tumor. C, Cell-type distribution heat map of RiboTag-depleted genes based on deconvolution of the profiles in A showing the expected, significant representation of all six cell types for genes that are not tumor-specific.