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. 2014 Aug 13;34(33):10989–11006. doi: 10.1523/JNEUROSCI.5110-13.2014

Figure 13.

Figure 13.

SCI causes upregulation of cyclin D1 and CDK4 proteins in the hippocampus and cerebral cortex at 12 weeks after injury. A, Representative cyclin D1 immunofluorecent images showing that SCI increased the total numbers of cyclin D1+ cells in both hippocampus (CA3) and cerebral cortex at 12 weeks after injury and such changes were limited by CR8 treatment. Scale bars, 100 μm. B, Representative Western blots for the cyclin D1 and CDK4 expression and the loading control (GAPDH). C, Quantification of protein band intensity showing significantly increased expression of cyclin D1 and CDK4 in the hippocampus and cerebral cortex at 12 weeks after injury, whereas CR8 treatment reversed elevation of cyclin D1 and CDK4 expression. *p < 0.05, ***p < 0.001 versus Sham mice; #p < 0.05, ###p < 0.001 versus SCI group. n = 5 (Sham), n = 8 (SCI), n = 7 (CR8).