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. 2014 Aug 13;34(33):10989–11006. doi: 10.1523/JNEUROSCI.5110-13.2014

Figure 2.

Figure 2.

Effects of contusion SCI in mice on hippocampus-dependent spatial learning and memory tested in MWM. A, Acquisition trials. A significant difference was detected between the Sham/Vehicle (n = 14) and SCI/Vehicle (n = 15) groups at training day 4 (***p < 0.001). No differences were found between the Sham/Vehicle (n = 14) and Sham/CR8 (n = 15) groups or the SCI/Vehicle (n = 16) and SCI/CR8 (n = 15) groups. B, Probe trial. SCI/Vehicle mice spent significantly less time in the target quadrant compared with Sham/Vehicle group (***p < 0.001) and the SCI/CR8 group (#p < 0.05). C, Search strategy. Looping type is predominant in the SCI/Vehicle group (63.2%) compared with the Sham/Vehicle group (7.4%), whereas SCI mice with CR8 treatment displayed increased spatial type (8.8% vs 4.4% from SCI/Vehicle mice) and reduced looping type (38.2%; χ2 = 63.03, p < 0.001). D, Representative types of search strategies. SCI mice showed less traveled distance than uninjured Sham mice.