Table 4.

Haplotype analysis of four SNPs (rs527434, rs9479757, rs632499, and rs13195018) between mild and severe groups

Haplotype*	Mild (n = 21)	Severe (n = 149)	p value
AGCA	0.618	0.798	0.0088
GGCA	0.095	0.094	0.9800
AGAC	0.095	0.037	0.8510
GAAC	0.071	0.030	0.1758
GAAA	0.071	0.020	0.0528

*The order of the SNPs as rs527434, rs9479757, rs632499, and rs13195018. Haplotypes, including the nominally significant SNPs, were constructed using Haploview version 4.2 by manually selecting the four SNPs to all be in the same haplotype block. Each haplotype was assessed for association with the dichotomous phenotype of mild vs severe groups (moderate group was not included) using the association test functions built into Haploview. Haplotypes with a frequency of <1% were excluded.