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. 2014 Aug 4;14:562. doi: 10.1186/1471-2407-14-562

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© Fukushima et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Silencing of MVP increases the cellular sensitivity to CDDP. A) The basal expression of MVP protein in KB/CDDP(T) cells and parental cells was analyzed using immunoblot analysis. B) The expression of MVP protein in KB/CDDP(T) cells treated with siRNA to MVP or negative control siRNA was analyzed using immunoblot analysis. Equal loading was confirmed by the detection of β-actin. C) The expression of MVP protein in KB/CDDP(T) cells treated with siRNA to MVP or negative control siRNA was analyzed using immunocytochemistry. D) The sensitivity of KB/CDDP(T) and parental cells treated with siRNA to MVP or negative control siRNA against CDDP was analyzed. Data are shown as the mean (n = 4).