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. 2014 Aug 4;14:562. doi: 10.1186/1471-2407-14-562

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© Fukushima et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Simultaneous exposure to ECyd and CDDP causes synergistic cell growth inhibition of cells with higher MVP expression levels. The effect of 24 hours of simultaneous exposure to ECyd and CDDP was analyzed in parental KB cells (A) and KB/CDDP(T) (B) cells. The combined effect of ECyd with CDDP was analyzed using an isobologram analysis according to the method described by Steel and Peckham. Data are shown as the mean (n = 4). C) The basal expression level of MVP protein in SHIN-3 and HRA cells was analyzed using immunoblot analysis. Equal loading was confirmed by the detection of β-actin. D) The combined effect of 24 hours of simultaneous exposure to ECyd and CDDP was analyzed in SHIN-3 (D) and HRA (E) cells. The combined effect of ECyd with CDDP was analyzed using bliss independent combination analysis. Data are shown as the mean (n = 4).