Table 2.
Summary of ORs of the HSP70 polymorphism and cancer risk.
| Variables | N | Dominant model | Recessive model | Ht versus WT Ho | VR Ho versus WT Ho | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P a | I 2 | OR (95% CI) | P a | I 2 | OR (95% CI) | P a | I 2 | OR (95% CI) | P a | I 2 | ||
| HSP70-2 | |||||||||||||
| Total | 17 | 1.53 (1.11, 2.09) | <0.00001 | 81 | 1.91 (1.06, 3.45) | <0.00001 | 87 | 1.38 (1.03, 1.84) | <0.00001 | 74 | 2.34 (1.21, 4.54) | <0.00001 | 88 |
| Ethnicity | |||||||||||||
| Asian | 7 | 1.96 (1.10, 3.51) | <0.00001 | 87 | 2.34 (0.94, 5.85) | <0.00001 | 86 | 1.67 (1.03, 2.71) | <0.0001 | 80 | 3.12 (0.99, 9.77) | <0.00001 | 89 |
| European | 4 | 1.06 (0.59, 1.89) | 0.0009 | 82 | 0.59 (0.29, 1.22) | 0.06 | 64 | 1.04 (0.54, 1.99) | 0.007 | 80 | 0.61 (0.23, 1.66) | 0.01 | 78 |
| African | 4 | 1.34 (1.00, 1.80) | 0.19 | 37 | 7.06 (2.33, 21.41) | 0.0009 | 82 | 1.09 (0.66, 1.82) | 0.11 | 51 | 7.56 (2.44, 23.39) | 0.005 | 77 |
| Mixed | 2 | 1.44 (0.45, 4.65) | 0.03 | 79 | 0.53 (0.31, 0.91) | 0.62 | 0 | 1.78 (0.55, 5.78) | 0.03 | 78 | 0.77 (0.27, 2.23) | 0.13 | 55 |
| Cancer type | |||||||||||||
| Hepatocellular | 3 | 2.41 (1.50, 3.87) | 0.06 | 65 | 4.98 (3.18, 7.79) | 0.19 | 40 | 1.80 (1.34, 2.42) | 0.38 | 0 | 6.07 (2.79, 13.19) | 0.10 | 57 |
| Breast | 3 | 1.16 (0.81, 1.64) | 0.29 | 19 | 3.61 (0.43, 30.28) | <0.00001 | 92 | 1.06 (0.55, 2.05) | 0.07 | 62 | 3.86 (0.56, 26.43) | 0.0002 | 88 |
| Others | 11 | 1.39 (0.93, 2.07) | <0.00001 | 82 | 1.13 (0.64, 2.00) | <0.00001 | 78 | 1.37 (0.92, 2.06) | <0.00001 | 78 | 1.43 (0.70, 2.93) | <0.00001 | 83 |
| Source of control | |||||||||||||
| PB | 11 | 1.57 (1.06, 2.34) | <0.00001 | 81 | 2.69 (1.21, 5.97) | <0.00001 | 87 | 1.44 (0.95, 2.16) | <0.00001 | 78 | 3.27 (1.36, 7.83) | <0.00001 | 87 |
| HB | 6 | 1.46 (0.83, 2.57) | <0.00001 | 84 | 1.17 (0.44, 3.09) | <0.00001 | 90 | 1.31 (0.86, 2.00) | 0.006 | 69 | 1.43 (0.46, 4.47) | <0.00001 | 90 |
| HSP70-hom | |||||||||||||
| Total | 10 | 0.85 (0.53, 1.37) | <0.00001 | 87 | 1.05 (0.50, 2.18) | 0.008 | 60 | 0.84 (0.55, 1.29) | <0.00001 | 83 | 0.98 (0.43, 2.24) | 0.001 | 68 |
| Ethnicity | |||||||||||||
| Asian | 4 | 0.55 (0.24, 1.28) | <0.00001 | 93 | 0.68 (0.14, 3.32) | 0.001 | 81 | 0.59 (0.28, 1.23) | <0.00001 | 91 | 0.57 (0.09, 3.42) | 0.0002 | 85 |
| European | 1 | 1.12 (0.71, 1.75) | NA | NA | 1.31 (0.56, 3.03) | NA | NA | 1.07 (0.66, 1.74) | NA | NA | 1.34 (0.57, 3.13) | NA | NA |
| African | 3 | 2.02 (0.41, 9.94) | <0.0001 | 90 | 3.03 (0.24, 38.65) | 0.04 | 70 | 1.79 (0.44, 7.29) | 0.0006 | 86 | 3.33 (0.20, 55.83) | 0.02 | 75 |
| Mixed | 2 | 0.61 (0.22, 1.68) | 0.11 | 61 | 0.63 (0.10, 3.88) | 0.97 | 0 | 0.64 (0.23, 1.77) | 0.11 | 61 | 0.59 (0.10, 3.64) | 0.95 | 0 |
| Source of control | |||||||||||||
| PB | 8 | 0.86 (0.49, 1.52) | <0.00001 | 89 | 0.87 (0.39, 1.94) | 0.008 | 63 | 0.85 (0.51, 1.42) | <0.00001 | 85 | 0.79 (0.32, 1.98) | 0.001 | 71 |
| HB | 2 | 0.78 (0.18, 3.50) | 0.008 | 86 | 3.58 (0.99, 12.93) | 0.26 | 23 | 0.77 (0.20, 2.97) | 0.02 | 82 | 3.66 (1.03, 13.02) | 0.19 | 42 |
| HSP70-1 | |||||||||||||
| Total | 5 | 1.30 (0.75, 2.24) | <0.00001 | 89 | 1.02 (0.52, 2.00) | 0.0008 | 79 | 1.26 (0.75, 2.12) | <0.0001 | 86 | 1.13 (0.52, 2.45) | 0.0001 | 83 |
N: number of studies; aTest for heterogeneity. CI, confidence interval; OR, odds ratio; Ht + VR Ho versus WT Ho, dominant model; VR Ho versus Ht + WT Ho, recessive model; NA, not applicable.