Table 2.
Summary of DXA studies of low bone mineral density (BMD) after childhood allogeneic HSCT
| N | Study design | Age at HSCT (y) | Age at study (y) | Follow-upa (y) | DXA Z-score | P value b | Height Z-score | ||
|---|---|---|---|---|---|---|---|---|---|
| Total body BMD | Lumbar spine BMD | ||||||||
| Bhatia et al. [64] | 10 | Cross-sectional | 5 (3–18) c | 12 (4–22) c | 2 (1–10) | –0.5 (–2.0 to 1.0) c | 0.05 | ||
| Nysom et al. [68] | 25 | Cross-sectional | 11 (6–18) c | 18 (11–27) c | 7 (4–13) | –0.5c | –0.5 c | 0.08; 0.54 | |
| Petryk et al. [69] | 21 | Longitudinal | 10 (5–18) d | 10 (5–18) d | ≤ 1 | ƒ–0.9 (–2.9 to 1.1) d | 0.022 | ||
| Perkins et al. [70] | 17 | Cross-sectional | 13 (4–24) d | 13 (4–24) d | 12 (3–22) d | –0.3 (–2.4 to 2.0) d | –1.8 | ||
HSCT hematopoietic stem cell transplant
aFollow-up y since HSCT
b P value compared with healthy controls
cMedian (range)
dMean (range)
ƒRepresents value at 1 year follow-up time point since HSCT compared with baseline; authors stated no change in lumbar spine BMD after adjusting for 1 year change in height SD but actual results not reported.