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. 2014 Jul 2;12(3):300–312. doi: 10.1007/s11914-014-0222-3

Table 2.

Summary of DXA studies of low bone mineral density (BMD) after childhood allogeneic HSCT

N Study design Age at HSCT (y) Age at study (y) Follow-upa (y) DXA Z-score P value b Height Z-score
Total body BMD Lumbar spine BMD
Bhatia et al. [64] 10 Cross-sectional 5 (3–18) c 12 (4–22) c 2 (1–10) –0.5 (–2.0 to 1.0) c 0.05
Nysom et al. [68] 25 Cross-sectional 11 (6–18) c 18 (11–27) c 7 (4–13) –0.5c –0.5 c 0.08; 0.54
Petryk et al. [69] 21 Longitudinal 10 (5–18) d 10 (5–18) d ≤ 1 ƒ–0.9 (–2.9 to 1.1) d 0.022
Perkins et al. [70] 17 Cross-sectional 13 (4–24) d 13 (4–24) d 12 (3–22) d –0.3 (–2.4 to 2.0) d –1.8

HSCT hematopoietic stem cell transplant

aFollow-up y since HSCT

b P value compared with healthy controls

cMedian (range)

dMean (range)

ƒRepresents value at 1 year follow-up time point since HSCT compared with baseline; authors stated no change in lumbar spine BMD after adjusting for 1 year change in height SD but actual results not reported.