Table 2.

Post-translational modifications within MeCP2 other than phosphorylation.

Residue	Mutation in RTT	PTM	Cell line/Tissue assayed	References
K12	K12N (0.04%)	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K82	K82fs (0.02%) K82R (0.02%)	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K119	–	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
	–	Met	293 T	Jung et al., 2008
K130	–	Ub	HEK-293T SH-SY5Y neuroblast. cells	Wagner et al., 2011; Gonzales et al., 2012
K135	K135E (0.15%)	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
R162	R162fs (0.06%)	Met	Kidney (7945, 7947)	www.PhosphoSite.org (Hornbeck et al., 2012), CST curation sets 7945, 7946, 7947, 7948, (Guo et al., 2014)
			Lung (7946, 7948)
			Mice brain
K210	K210I (0.02%)	Met	293 T	Jung et al., 2008
K223	K223NfsX3 (0.02%)	SUMO	Primary cortical neurons	Cheng et al., 2014
K233	K233fs (0.02%)	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K249	–	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K256	K256SfsX17 (0.02%)	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K271	–	Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K305	K305fs (0.02%) K305E (0.02%) K305R (0.08%)	Ac	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K307	–	Ac	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
K321	K321Sfs*13 (0.02%)	Ac	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
		Ub	SH-SY5Y neuroblast. cells	Gonzales et al., 2012
T436	–	O-GlcNAc	Murine synaptosomes (Trinidad et al., 2012)	Wang et al., 2010; Trinidad et al., 2012
			Rat brain (Wang et al., 2010)
T442	T442fs (0.02%)	O-GlcNAc	Rat brain	Wang et al., 2010
	T442A (0.02%)
K449	–	Ac	MV4-11 (Choudhary et al., 2009)	(Choudhary et al., 2009)
			HCT 116 (CST)	www.PhosphoSite.org (Hornbeck et al., 2012), CST curation sets 9796, 9797
K461	–	Ac	HEK-293 cells and primary cortical neurons	(Zocchi and Sassone-Corsi, 2012)