Figure 13. Illustration of the proposed data normalization method.

The proposed data normalization method enhances tissue patterns, reduces stain variation, and assists the following identification of corresponding landmarks and image registration. (a) the source image, (b) the target image, (c) and (d) are the images applied with the presented data normalization method with automatically identified corresponding landmarks, (e) and (f) are images with deformation grid, (g) is the deformation field, and (h) is the transformed source image that is well aligned to the target image.