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. 2014 Aug 13;4:6050. doi: 10.1038/srep06050

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The processing time (in seconds) on brain image registration by the proposed method, the semi-automatic brainAligner and the automatic brainAligner. The processing time for the semi-automatic brainAligner does not include the time for manually marking corresponding landmarks as this information is unknown in this study. Since the manual marking time is often lengthy, therefore the processing time by the semi-automatic brainAligner is greatly underestimated. Comparing the automatic approaches, the proposed method is significantly faster than the brainAligner approach (p < 0.001 based on Tukey HSD and LSD tests) and costs 3.79 second per registration.