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. 2014 Aug 1;5:22. doi: 10.1186/1759-8753-5-22

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Copyright © 2014 Yamanaka et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Three types of Piwi-interacting RNA (piRNA) cluster. (A) Unistrand piRNA cluster; piRNAs are produced from only one genomic DNA strand. (B) Dual-strand piRNA cluster; piRNAs are produced from both strands of the same genomic region. (C) Bidirectional piRNA cluster; two unistrand piRNA clusters are arranged in a divergent manner.