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. 2014 Feb 14;28(8):1657–1665. doi: 10.1038/leu.2014.44

Figure 2.

Figure 2

ABT-737 compared with ABT-199 in vitro synergy with 5-Azacytidine. (a) Maximal 5-Aza EC50 fold-shifts for ABT-737 and ABT-199 are shown side-by-side for each cell line. These EC50 fold-shifts are a ‘one-sided' measurement of 5-Aza enhancement. (b) Corresponding ABT-737 or ABT-199 doses at which maximal 5-Aza EC50 fold-shifts occurred are shown side-by-side. (c) *CalcuSyn Combination Index (CI) values corresponding to the greatest synergy (thus doses shown in b) nearest to the 5-Aza EC50 dose are listed. It is important to note that CI values are a ‘two-sided' measurement of drug synergy for two specific doses, thus a single CI value is not a universal characteristic of the interaction between two drugs because interactions can be dose dependent. See Supplementary Figure 2B for an extensive data set of CI values across multiple dose combinations plotted against the corresponding Fractional Effect, where 0=no effect and 1.0=maximal effect. CI values <0.8 indicate synergy, whereas CI values >1.1 indicate antagonism.