Table 1a. In vitro % viability reduction by siRNA alone.
| Cell line |
siRNA |
||
|---|---|---|---|
| BCL-2 | BCL-XL | MCL-1 | |
| SET-2 | 0–2 | 39–52 | 22–65 |
| TF-1 | 0–4 | 11–71 | 0–17 |
| HEL | 0–1 | 21–67 | 14–39 |
| THP-1 | 0–21 | 11–32 | 33–87 |
| OCI-AML3 | 0–20 | 66–71 | 49–99 |
| ML-2 | 0–4 | 11–38 | 18–35 |
Antiapoptotic BCL-2 family siRNA drug-dose-response assays with 5-Azacytidine in myeloid cells in vitro. Cell lines are listed in the left-most column. The BCL-2 family member silenced by siRNA is shown as the heading for each column. The range of % viability reduction due to the given siRNA alone (without 5-Aza) is shown (0=no affect and 100= maximal reduction in viability).