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. 2014 Aug 13;6:17. doi: 10.3389/fnsyn.2014.00017

Figure 1.

Figure 1

Oxotremorine treatment attenuates spontaneous self-grooming behavior in BTBR mice. Mean (±SEM) time spent grooming all body regions. Self-grooming behavior was measured in BTBR and B6 mice. Each mouse received an i.p. injection of vehicle, 0.001 or 0.01 mg of oxotremorine 30 min before grooming behavior was measured. BTBR mice spent significantly more time grooming compared to that of B6 mice. Vehicle or oxotremorine treatment did not affect spontaneous grooming behavior in B6 mice. Oxotremorine at 0.01 mg significantly decreased spontaneous grooming in BTBR mice. B6: vehicle (n = 8), 0.001 (n = 8), 0.01 (n = 8), BTBR: vehicle (n = 9), 0.001 oxo (n = 9), 0.01 oxo (n = 9). ** p < 0.01 vs. B6-vehicle, ## p < 0.01 vs. BTBR-vehicle.