Figure 2.
Oxotremorine treatment attenuates marble burying in BTBR mice. Mean (±SEM) marbles buried. Marble burying was measured in BTBR and B6 mice. Each mouse received an i.p. injection of vehicle, 0.001 or 0.01 mg of oxotremorine 30 min prior to marble exposure. BTBR mice buried significantly more marbles compared to that of B6 mice. Vehicle or oxotremorine treatment did not significantly affect marble burying in B6 mice. Oxotremorine at 0.01 mg significantly decreased marble burying in BTBR mice. B6: vehicle (n = 9), 0.001 oxo (n = 8), 0.01 oxo (n = 8), BTBR: vehicle (n = 9), 0.001 oxo (n = 9), 0.01 oxo (n = 9). ** p < 0.01 vs. B6-vehicle, ## p < 0.01 vs. BTBR vehicle.