Table 2.

Osteogenesis potential between bone marrow mesenchymal stem cells and adipose-derived stem cells in animal model

Ref.	Animal model	Scaffold	Analytic methods	Outcome of osteogenic ability
Hayashi et al[27]	Subcutaneous implantation in rat	Hydroxyapatite	Micro-CT	New bone volume BMSC (6.85 ± 1.89 mm3) > ASC (0.05 ± 0.05 mm3)
Niemeyer et al[32]	3-cm tibial defect in sheep	Collagen sponge	Radiographic and histologic analysis	BMSC > ASC BMSC = ASC + PRP No original data for bone volume
Kang et al[23]	1.5-cm radial bone defect in dog	Tricalcium phosphate	Radiographic, histological and histomorphometric analysis	New bone percentage: BMSC (33.56%) = ASC (33.9%)
Stockmann et al[33]	1-cm calvarial bone defect in pig	Bovine collagen type I	Microradiography, histomorphometric evaluation	BMSC = ASC No original data for bone volume
Wen et al[34]	5-mm calvarial defect in SD rat	Collagen gel	X-ray and histology	BMSC = ASC No original data for bone volume
Zhang et al[21]	Subcutaneous pocket of nude mice	PCL/TCP	Micro-CT	New bone volume: BMSC (16.6 ± 3.0 mm3) > ASC (9.1 ± 1.1 mm3)

BMSC: Bone marrow mesenchymal stem cell; ASC: Adipose-derived stem cell; PRP: Platelet rich plasma; PCL/TCP: Polycaprolactone/tricalcium phosphate; CT: Computed tomography.