Table 3.

Summary of enrichment analysis of genes down-regulated in Gsk-3 DKO, p110*, and S33A ESCs.

Name	ID	p-Value	Hit count
GSK-3 DKO ESCs
GO: molecular function
Sequence-specific DNA binding	GO:0043565	8.59 × 10−13	109/726
Sequence-specific DNA binding transcription factor activity	GO:0003700	7.28 × 10−12	141/1067
GO: biological process
Cardiovascular system development	GO:00722358	2.15 × 10−21	148/871
Pathway
Extracellular matrix organization		1.40 × 10−9	50/264
Elastic fiber formation		1.51 × 10−7	15/41
P110* ESCs
GO: molecular function
Receptor binding	GO:0005102	1.51 × 10−11	133/1341
GO: biological process
Organ morphogenesis	GO:0009887	2.09 × 10−34	147/876
Extracellular matrix organization	GO:0030198	1.59 × 10−22	70/330
Cardiovascular system development	GO:0072358	2.34 × 10−22	124/871
Pathway
Extracellular matrix organization		6.17 × 10−16	54/264
S33A ESCs
GO: molecular function
Sequence-specific DNA binding	GO:0043565	2.15 × 10−10	81/726
Sequence-specific DNA binding transcription factor activity	GO:0003700	3.54 × 10−10	105/1067
GO: biological process
Neurogenesis	GO:0022008	3.88 × 10−15	143/1360
Extracellular matrix organization	GO:0072358	1.21 × 10−14	104/871

Bonferroni correction method.

All p-Value cutoffs – 0.05.